Immuneering Recognizes Melanoma Awareness Month - Seite 2

At the AACR-NCI-EORTC conference in October 2023, Immuneering presented preclinical data including expanded benchmarking of IMM-1-104 as a single agent across more than 190 patient-aligned models in humanized 3D-tumor growth assays, which demonstrated high sensitivity in a wide range of MAPK-driven tumor types, including models of RAS and RAF mutant melanoma, as well as pancreatic cancer, and lung cancer. Preclinical data the company has presented related to melanoma includes data showing that IMM-1-104 inhibits tumor growth in an animal model of NRAS mutant melanoma to a greater extent than binimetinib, and that IMM-6-415 in combination with encorafenib inhibits tumor growth in an animal model of BRAF mutant melanoma to a greater extent that binimetinib plus encorafenib.

IMM-1-104 aims to achieve universal-RAS activity that selectively impacts cancer cells to a greater extent than healthy cells, through Deep Cyclic Inhibition of the MAPK pathway with once-daily dosing. In the Phase 2a portion of Immuneering’s ongoing IMM-1-104 Phase 1/2a clinical trial (NCT05585320), IMM-1-104 is being evaluated as both monotherapy and in select combinations with approved chemotherapeutic agents. The Phase 2a portion includes five arms, one of which focuses on RAS-mutant melanoma, another focused on RAS mutant non-small cell lung cancer (NSCLC), and three arms focused on patients with pancreatic cancer. The company expects initial data from multiple Phase 2a arms in 2024.

IMM-6-415 is a Deep Cyclic Inhibitor of the MAPK pathway designed with unique drug-like properties including a shorter half-life for an accelerated cadence. IMM-6-415 is currently being evaluated in a Phase 1/2a study in patients with advanced solid tumors harboring RAF or RAS mutations. (NCT06208124). The Phase 1 portion of the Phase 1/2a clinical trial is an open-label study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of IMM-6-415 in patients with advanced RAF/RAS mutant solid tumors. The trial will include solid tumor patients with any mutation in RAF, KRAS, NRAS, or HRAS who meet the enrollment criteria. The company expects initial PK, PD and safety data for IMM-6-415 in 2024.